Individuals with Alzheimer’s disease are more often hospitalised after initiating antibiotic use

Individuals with Alzheimer’s disease (AD) are more often hospitalised after antibiotic initiation than people without AD, a new study from the University of Eastern Finland shows. The risk of hospitalisation was 40 per cent higher for persons with Alzheimer’s disease. The findings were published in Journal of Alzheimer’s Disease.

Of individual antibiotics, persons with Alzheimer’s disease were more often hospitalised than people without AD after the initiation of cephalexine, pivmecillinam, amoxicillin and doxycycline. Hospitalisation was associated with pre-existing illnesses, such as epilepsy or cancer, and certain medications, such as antipsychotic and benzodiazepine use.

This study used data from a Finnish register-based cohort, which includes all persons diagnosed with Alzheimer’s disease in Finland during 2005–2011. The researchers analysed 34,785 individuals who used antibiotics in an outpatient setting after their Alzheimer’s disease diagnosis, and their comparison persons matched according to age, sex and region of residence.

Previous studies have shown that infections are a significant cause of hospitalisation in people with dementia. This study is the first to document hospitalisation after antibiotic initiation. These results confirm the role of infections as a cause of hospitalisation in persons with Alzheimer’s disease.

Follow the link to read the abstract:

Järvinen H, Taipale H, Koponen M et al. Hospitalisation after oral antibiotic initiation in Finnish community dwellers with and without Alzheimer's Disease: retrospective register-based cohort study. J Alzheim Dis. Published online 19 June 2018 DOI: 10.3233/JAD-180125

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